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KMID : 0357920100440060565
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Korean Journal of Pathology
2010 Volume.44 No. 6 p.565 ~ p.570
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Uncoupling Protein 2 (UCP2) and p53 Expression in Invasive Ductal Carcinoma of Breast
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Won Kyu-Yeoun
Kim Gou-Young
Kim Youn-Hwa
Lim Sung-Jig
Song Jeong-Yoon
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Abstract
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Background : Uncoupling protein 2 (UCP2) is a recently identified mitochondrial inner membrane anion carrier and a negative regulator of reactive oxygen species production. In this study, we evaluated the characteristics and relationships of UCP2 and p53 expression in breast cancer tissues.
Methods : Tissue microarray slides from 107 cases of invasive ductal carcinoma of the breast were constructed, UCP2 and p53 immunohistochemical staining was conducted, and clinicopathological correlations were investigated.
Results : UCP2 expression in invasive ductal carcinoma was high in 53 cases (49.5%), while p53 expression in invasive ductal carcinoma was high in 37 cases (34.6%). UCP2 expression was correlated significantly with histological grade (p = 0.038) and mitotic count (p = 0.050). UCP2 expression was correlated significantly with p53 expression in invasive ductal carcinoma of the breast (p = 0.045). UCP2 expression (p = 0.8308) and p53 expression (p = 0.3292) showed no significant difference for the overall survival rate in patients with invasive ductal carcinoma.
Conclusions : UCP2 expression in invasive ductal carcinoma increased proportionally with histological grade and mitotic count. High UCP2 expression in invasive ductal carcinoma was observed in conjunction with high p53 expression.
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KEYWORD
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Carcinoma, ductal, breast, Mitochondrial uncoupling protein 2, Tumor suppressor protein p53, Reactive oxygen species
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